It is important to highlight that the results by Santana et al.are with PBMCs from healthy volunteers (Hb AA genotype) and HUVECs,which still have a nucleus as well as cytoplasmic organelles while here, we evaluated transcript levels inreticulocytes, which are immature forms of RBC in the final stagesof differentiation (i.e., cells without the presence of the nucleus), from SCA patients. This evidence concerns the gene GSTM1 and autosomal dominant cerebellar ataxia.