ATF4 and autosomal dominant cerebellar ataxia: ATF4 directly stimulates the transcriptionof BCL11A, a repressor of γ-globin transcription,by binding to its enhancer and fostering enhancer-promoter contacts. Furthermore, mRNA level analysis of patientswith SCA during vaso-occlusive crises and in a steady state, comparedwith age-matched healthy patients, highlights both NRF2 and ATF4 differential expressions, indicating thatthey are possible candidates involved in the severity of this pathology.