TNF and neoplasm: Interferon gamma (IFN) as well as tumour necrosis factor alpha (TNF) are created by Tc1 cells and have a strong anti-tumor impact, but interleukin (IL)-4, and IL-10, as well as IL-5, secreted through Tc2 cells have a minor to no effect on tumor formation (Qi et al., 2017; Wang et al., 2016b).