BDNF and Mental deterioration: 2017; Franzmeier et al. 2021; Lim et al. 2021) and schizophrenia (Farcas, Hindmarch, and Iftene 2023; Schweiger et al. 2019; Ursini et al. 2016), the rs6265 (Val66Met) polymorphism could often be associated with a negative effect on cognition, with the Met (A) allele linked to reduced BDNF production and cognitive decline. However, these findings may not generalize to brain injuries like TBI or stroke, where BDNF’s role varies by injury‐specific and molecular contexts.