In our cohort of 14 patients with confirmed liver fibrosis, targeted analysis of CHIP-associated driver mutations in peripheral blood leukocytes revealed the following distribution of canonical age-related variants: TRP53 mutations were detected in three cases (21.4%), ASXL1 in one case (7.1%), DNMT3A in two cases (14.3%), and TET2 in three cases (21.4%). Here, TP53 is linked to Hepatic fibrosis.