Our findings reveal that Tet2−/− pMDMs are a major source of elevated Ccl2 and Ccl8 in Tet2ΔMye-CCl4 mice, and Tet2−/− monocytes showed an increased expression of Ccr2 and Ccr3, which, thus, created a positive feedback loop that amplifies MDMs infiltration and liver fibrosis. The gene discussed is CCR2; the disease is Hepatic fibrosis.