To investigate the impact of Tet2 deficiency on liver fibrosis progression under chronic injury, we established a carbon tetrachloride (CCl4)-induced liver fibrosis model in systemic Tet2 KO (Tet2ΔSys) mice, hepatocyte-specific Tet2 KO (Tet2ΔAlb) mice, and myeloid cell–specific Tet2 KO (Tet2ΔMye) mice (Fig. S1 A). Here, TET2 is linked to Hepatic fibrosis.