Our findings reveal that Tet2−/− pMDMs are a major source of elevated Ccl2 and Ccl8 in Tet2ΔMye-CCl4 mice, and Tet2−/− monocytes showed an increased expression of Ccr2 and Ccr3, which, thus, created a positive feedback loop that amplifies MDMs infiltration and liver fibrosis. This evidence concerns the gene CCL8 and Hepatic fibrosis.