In a large prospective Chinese cohort (n = 450), elevated glycated hemoglobin (HbA1c ≥ 6.5%)—but not fasting glucose—was significantly associated with increased mortality (adjusted HR = 2.06; 95% CI: 1.07–3.96), whereas standard Hb was not assessed, suggesting that chronic glycemic dysregulation may modulate ALS progression (Wei, Chen et al. The gene discussed is GSTM1; the disease is amyotrophic lateral sclerosis.