We extracted summary statistical data of Hb concentration and ALS from genome‐wide association studies (GWAS), performed Mendelian randomization (MR) analyses, and conducted RNA sequencing of motor neurons different from ALS patient‐derived induced pluripotent stem cells (iPSCs), followed by an intersection analysis between differentially expressed genes (DEGs) in ALS motor neurons and selected instrumental variables (IVs) associated with Hb concentration. This evidence concerns the gene GSTM1 and amyotrophic lateral sclerosis.