TARDBP and amyotrophic lateral sclerosis: About 5–10% of ALS cases are familial ALS (fALS), primarily resulting from mutations in certain genes such as SOD1, FUS, TARDBP (TDP‐43), VAPB, MATR3 (matrin‐3), and ATXN2 (ataxin‐2) (Yousefian‐Jazi et al.