In this study, prognostic genes related to mitochondria and macrophage polarization in PRAD were obtained through bioinformatics methods such as differential expression analysis, WGCNA, and MR: ABHD11, PTRH2, CAT, NTHL1, SLC25A39, OXR1, and GSTZ1. Here, ABHD11 is linked to prostate adenocarcinoma.