Additionally, immunofluorescence analysis of excised tumors confirmed strong suppression of key tumor‐associated proteins: tissue factor was reduced by 90% in both groups (p = 0.003 and p = 0.0048 for ISOQ3/ZAF10 and ISOQ10/ZAF10, respectively), VEGF expression was reduced by 90% and 95% (both p = 0.0008), TMEM176B by 66% and 80.5% in the ISOQ3/ZAF10 and ISOQ10/ZAF10 groups, respectively (p = 0.025 and p = 0.0117), and PD‐L1 was reduced by 87% and 91% (p < 0.0001 for both groups) (Figure 7B–E). This evidence concerns the gene TMEM176B and neoplasm.