For example, the gut bacterial pathway GLCMANNANAUT.PWY (N‐acetylglucosamine, N‐acetylmannosamine, and N‐acetylneuraminic acid degradation superpathway) showed a positive association with CD4+CD8+ T cell absolute count (β.x = 0.147, p.x = 0.003, OR.x = 1.158), with a direct positive effect on congenital malformations of the nervous system (β.y = 0.657, p.y = 0.040, OR.y = 1.930) and a mediating effect of 0.097. The gene discussed is CD8A; the disease is congenital nervous system disorder.