Conversely, CD4+CD8+ T cell absolute count, CD25 on IgD+ CD38dim B cell, and CD25 on IgD− CD24− B cell (β values of 0.657, 0.569, and 1.325, respectively, p < 0.05) were positively associated with higher risk of congenital malformations of the nervous system. The gene discussed is CD8A; the disease is central nervous system malformation.