Their link is reciprocal and understanding its nature, particularly over time, could improve the health of many.<h4>Methods</h4>A prospective study was conducted to examine the development of the two main components of CKD (urine albumin/creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR)) over 24 years (2001-2024) in a sample of 718 individuals with a diagnosis of T2D. This evidence concerns the gene ALB and type 2 diabetes mellitus.