Briefly, the type 2 endotype, mediated by multiple inflammatory factors (including IL-5, IL-4, IL-13, eosinophilic cationic protein - ECP, and periostin), is characterized by tissue eosinophilia and increased IgE production, associating with asthma, non-steroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) and allergic fungal rhinosinusitis (6, 11, 22, 23). The gene discussed is IGHE; the disease is asthma.