However, in everyday clinical practice the tools available for CRS endotyping are decidedly narrower: clinicians typically rely on clinical features (i.e., comorbidities such as asthma and N-ERD which associated with the type 2 endotype) along with blood eosinophil and total IgE levels and, when available, a standard histologic evaluation of the nasal mucosa. The gene discussed is IGHE; the disease is asthma.