TGF-β further polarizes TANs to the pro-tumor N2 phenotype, whereas blocking TGF-βpromotes the accumulation of N1-TANs and upregulates chemotaxis/adherence and cytotoxic-related programs (such as CXCL1/2/5, ICAM-1), synergizing with CD8+ T cells to suppress tumor growth (Fridlender et al., 2009). This evidence concerns the gene TGFB1 and neoplasm.