We also did not detect a concomitant upregulation in GAPDH, which has been suggested to be a pan-cancer marker that promotes growth, therapeutic resistance, and metastatic dissemination, as reviewed in Ref.65 A reduction in GAPDH with a concomitant decrease in ETMR cell growth correlates with previously published studies that show downregulation of GAPDH results in reduced tumor cell growth and proliferation.66 The gene discussed is GAPDH; the disease is cancer.