For instance, the HRDetect system, used to detect HRR deficiency caused by BRCA1/2 mutations, has been successfully applied to predict tumor response to platinum‐based agents; additionally, RAD51 gene alterations significantly reduce tumor cell migration and invasion, and increase hepatocellular carcinoma sensitivity to chemotherapeutic agents by blocking HRR [45]. Here, BRCA1 is linked to neoplasm.