For instance, Ataxia Telangiectasia Mutated (ATM) inhibitors can suppress the expression of ATM protein in cells, thereby compromising DDR efficacy; Poly ADP‐Ribose Polymerase (PARP) inhibitors (PARPi) block the expression of PARP enzymes involved in DDR, resulting in DNA damage accumulation and ultimately triggering cancer cell apoptosis [19]. The gene discussed is ATM; the disease is cancer.