Novel composite indices such as the Hemoglobin, Albumin, Lymphocyte, and Platelet score (HALP), the Pan-Immune-Inflammation Value (PIV), and the Systemic-Immune-Inflammation Index (SII) offer broader insights, HALP reflects nutritional immune balance, PIV quantifies innate-adaptive immune dynamics, and SII assesses thromboinflammatory activity (Kından et al., 2025; Okyar Baş et al., 2023; Xia et al., 2023), yet their application in AD remains largely unexplored. This evidence concerns the gene ALB and Alzheimer disease.