Moreover, PCOS-related acne patients showed a higher chance of having comorbid hirsutism or/and androgenic alopecia than non-PCOS-related acne patients; their main testosterone levels were notably higher, while their LH/FSH ratio surpassed 1 in over 70% of cases (a twofold higher percentage compared to non-PCOS-related acne patients). Here, PLOD1 is linked to acne.