AR and acne: Complementary to COCPs, one more substance that is widely used to treat PCOS-associated acne is spironolactone, an effective androgen receptor antagonist (and also a 5α-reductase inhibitor), which has the ability to reduce the impact of androgens on sebaceous glands (and sebum production) by blocking androgen receptors in the skin, leading to amelioration of acne [58].