For CRSwNP patients with AR in this study, increased total IgE usually indicates the presence of a Th2-type inflammation, which promotes mast cells or basophils to release histamine, leukotrienes, IL-4, and IL-13, causing nasal mucosal edema, itching, and increased secretions (23). This evidence concerns the gene IL13 and chronic rhinosinusitis with nasal polyps.