BCR and chronic myelogenous leukemia, BCR-ABL1 positive: Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia (Ph+) chromosome (generated by a reciprocal translocation between Chromosomes 9 and 22) and its oncogene BCR::ABL1, encoding a constitutively active tyrosine kinase that is found in > 90% of CML patients [1, 2].