EGFR and central nervous system cancer: An aptamer specifically binding to the mutant EGFR ([68Ga]-NOTA-EGFRvIII) was tested in a xenograft mouse cell model of U87MG glioma expressing either EGFR or EGFRvIII that was injected subcutaneously and showed binding to EGFRvIII but no binding to conventional EGFR on micro-PET imaging (24).