In multiple myeloma (MM), IRE1 has a tumor-growth-promoting role, while in B-cell lymphoma germinal center B-cell-like subtype (GCB-DLBCL), IRE1/XBP1s activity may negatively impact tumor growth (Bujisic et al., 2017). Here, ERN1 is linked to B-cell non-Hodgkin lymphoma.