KMT5B and head and neck squamous cell carcinoma: Regarding the effect of SUV420H1 on the genome-wide deposition of H4K20me3 in HPV-negative HNSCC cells, CUT&RUN profiling in A-196-treated HPV-negative HNSCC cells revealed a genome-wide loss of predominantly intragenic H4K20me3 peaks, implicating SUV420H1 as the primary regulator of H4K20me3 deposition in HPV-negative HNSCC.