STING1 and head and neck squamous cell carcinoma: While STING1 was significantly upregulated in the siSUV420H1 but not the A-196 RNA-seq dataset (Supplementary Table 2), the possibility that SUV420H1 may also silence retransposon sequences through H4K20me3 further repressing IFN responses in HPV-negative HNSCC cells would need to be further and more systematically interrogated through whole RNA-sequencing experiments.