IFNA1 and melanoma: Ramponi et al. also recently demonstrated that SUV420H1/2-mediated H4K20me3 directly represses IFN-response gene expression at or near promoters in persister cancer cells, and that SUV420H1 depletion leads to robust activation of IFN-response programs in human melanoma, non-small cell lung cancer and breast cancer cell lines (21).