The aforementioned results suggest that SUV420H1 promotes an immunosuppressive TIME, possibly through transcriptional regulation of myeloid-attracting chemokine/cytokine genes, such as IL1A, IL1B, LPAR1, CXCL1, CXCL8, IL15, IL6 and CXCL17, which alter the balance of anti-tumor macrophages/pro-tumorigenic MDSCs towards a pro-tumorigenic TIME. This evidence concerns the gene IL1B and neoplasm.