These results are in accordance with the GSEA analysis in the HPV-negative HNSCC and LUSCC cohort of the TCGA (Fig. 1C), our observed phenotypes of decreased proliferative potential and invasive capacity with human SUV420H1 depletion in vitro (Fig. 2B, C, Fig. 3A, B, D), enhanced immune response with mouse Suv420h1 depletion in vivo (Fig. 4), as well as with decreased invasive capacity with human SUV420H1 inhibition (Fig. 3. The gene discussed is KMT5B; the disease is head and neck squamous cell carcinoma.