Accordingly, SUV420H1 mRNA expression was higher in HPV-negative HNSCC and lung SCC tumors with SUV420H1 gain, and even higher in tumors with SUV420H1 amplification compared to tumors that were diploid for the SUV420H1 gene (Fig. 1B). The gene discussed is KMT5B; the disease is head and neck squamous cell carcinoma.