KMT5B and head and neck squamous cell carcinoma: In accordance with the results with human HPV-negative HNSCC cell lines (Fig. 2B, 2C, 2G), the colony forming capacity of two Suv420h1 KO MOC1 cell lines (KO-1, KO-2) (Fig. 4A), as well as the global levels of H4k20me3 levels were decreased (Fig. 4B) compared to the parental MOC1 cells (negative control, NT).