Regarding the effect of Suv420h1 on the TIME, while we identified a possible role of macrophages in the anti-tumor efficacy and synergy of Suv420h1 KO with anti-PD-1, macrophage depletion experiments in Suv420h1 KO tumors treated with anti-PD-1 will be necessary to validate the functional role of macrophages in this context. Here, KMT5B is linked to neoplasm.