Amongst other squamous cell carcinomas (SCCs) which have a similar genetic background as HPV-negative HNSCC (15), a similar gain/amplification rate of SUV420H1 was also observed in lung (~28%) and bladder urothelial carcinoma (~27%), with a lower rate in cervical SCC (12%) (Supplementary Fig. 1). Here, KMT5B is linked to head and neck squamous cell carcinoma.