Importantly, despite the only modest and non-significant increase in intratumoral CD8+ T-cells and a predominant effect on the myeloid compartment, Suv420h1 KO MOC1 tumors exhibited enhanced sensitivity to anti-PD-1 therapy, further potentiating the anti-tumor efficacy of Suv42h0h1 KO (Fig. 4D). Here, KMT5B is linked to neoplasm.