SPP1 and heart failure: On the other hand, unlike Rosi, TPMD shows little or no induction on the expression of genes involved in heart failure or hypertrophy, including β-Mhc, Nppb, Bnp, and Acta1, in the heart, on osteogenic/bone forming genes (Osteocalcin, Col1a1, Alp, Spp1) in the bone or bone marrow, or on adipogenic genes (Pparg2, Cfd, aP2, Perilipin, Adipoq) in the adipose tissue, which are associated with PPARγ agonism.