Clusters 1, 2, and 4 represented melanocytic states, characterized by the highest levels of SOX10 and PMEL expression (Fig. 6c; Supplementary Fig. 7e) but with differences in the expression of S100 proteins: clusters 2 and 4 were S100B-high and predominantly located in tumor Domains A and B, while cluster 1 was S100A1-high and most prevalent in other domains (Fig. 6d, e; Supplementary Fig. 7f). The gene discussed is PMEL; the disease is neoplasm.