CD163 and neoplasm: ORION images of biopsies from the five additional specimens in the Buchbinder et al.(5) cohort for which tissue was still available (MEL102 to MEL106; Fig. 1a) revealed the presence of SOX10+ tumor cells in specimen MEL105 but no other specimens; MEL106 contained only fibrotic tissue, and the other biopsy specimens contained fibrotic tissue with infiltrating Treg and CD8+ T cells, CD163+ macrophages, CD20+ B cells, and CD11C+ myeloid cells, (Supplementary Fig. 8a).