Widmer Widmer DS DS ,  Hoek Hoek KS KS ,  Cheng Cheng PF PF ,  Eichhoff Eichhoff OM OM ,  Biedermann Biedermann T T ,  Raaijmakers Raaijmakers MIG MIG ,  Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching . The gene discussed is HIF1A; the disease is melanoma.