Under conditions of hyperinsulinemia, more urate is reabsorbed (64–69)by the urate reabsorption transporters (especially by GLUT9 and OAT10) (15) in proximal tubule cells, resulting in HUA in the absence of renal dysfunction because proximal tubule cells retain their sensitivity to insulin in the state of insulin resistance (70). This evidence concerns the gene SLC22A13 and Insulin resistance.