BACE1 and Alzheimer disease: Furthermore, neuroprotectin D1, a stereoselective mediator derived from DHA has a protective effect against Aβ42 production by modulating key proteins involved in the processing of β-amyloid precursor protein, including peroxisome proliferator-activated receptor gamma (PPARγ)-dependent expression of BACE1, disintegrin and metalloproteinase 10 (ADAM10), and soluble amyloid precursor protein alpha (sAPPα), in 3xTg-AD mouse models and human neuronal-glial cells in primary culture (239).