Additionally, vitamin D supplementation ameliorated cognitive impairment and altered neurodegenerative (Aβ1-40, Aβ1-42, p-Tau, and Neprilysin) and inflammatory markers (IL-6, IL-1β, TNF-α, and NF-κβ) in the scopolamine-induced rat model (222). This evidence concerns the gene TNF and Cognitive impairment.