↓ Aβ aggregation ↓ptau ↓ inflammation ↓ LVSCC-A1C and LVSCC-A1D ↑ nerve growth factors ↑neural stem cell proliferation and oligodendrocyte differentiation. ↑ NT-3, BDNF, GDNF and CNTF ↑ cognitive impairment ↑ miR-9-3p. The gene discussed is GDNF; the disease is Cognitive impairment.