Healthy Eating Index-2020 (HEI-2020) and the Dietary Inflammatory Index (DII) analyses revealed significant associations between elevated interleukin (IL)-6, IL-1β, lipopolysaccharide binding protein, Toll-like receptor 4 (TLR4), as well as zonula occludens-1 (ZO-1) and cognitive impairment, highlighting inflammation as a key modifiable target (31). The gene discussed is TLR4; the disease is Cognitive impairment.