FGF2 and Cognitive impairment: Specifically, clinical trials of RSV have shown efficacy in improving cognitive impairments through modulation of pro-inflammatory cytokines and molecules related to neurodegeneration, including IL-10, IL-4, IL-12P40, IL-12P70, Fibroblast Growth Factor-2 (FGF2), regulated on activation, normal T-cell expressed and secreted (RANTES), and metalloproteinase (MMP)- 9 (110, 111).