With this background, we examined the symptoms of migraine and its comorbidities, the 14 food-specific IgG antigens, IL-6, IL-10 and TNF-α, 5-HT, CGRP, and VIP, of adult migrant patients, and conducted a randomized controlled trial to compare the changes by two different food-specific IgG-based elimination diets. This evidence concerns the gene IL6 and migraine disorder.