This exploratory study allowed the prioritization of three potential biomarkers with the highest contribution to post-surgical sepsis prediction (rs17653532, rs1575081785, and rs74707084) located in PRIM2, RBSN, and SYNPR genes, which are involved in integrative processes, such as gene expression regulation, DNA replication, and cell proliferation. The gene discussed is RBSN; the disease is Sepsis.