Our group recently discoveredthat prohibitin-1 (PHB1) is a plasma protein that sharply increasesin concentration within the first 12 h of septicemia. PHB1 and its isoform PHB2 are relatively small proteins(M.W. 30–34 kDa) that form a ring-like hetero-oligomeric complexwithin the plasma and mitochondrial inner membranes, where they regulatepleiotropic functions including cellular proliferation, metabolism,and apoptosis. This evidence concerns the gene PHB1 and Sepsis.