IGF1 and acromegaly: Acromegaly is caused in more than 95% of cases by a GH-secreting pituitary adenoma [19] and is characterized by chronic exposure to supraphysiological GH and IGF-1 levels, resulting in a higher incidence of metabolic diseases—such as diabetes mellitus (DM) and dyslipidemia—as well as cardiovascular disease and other comorbidities [20].