Following genome-wide gene screening and molecular docking simulation, we have identified the key renal receptors (<i>Itga3</i>, <i>Itga5</i>, <i>Tgfbr1</i>, etc.)and regulators (<i>Jun</i>, <i>Junb</i>, <i>Stat1</i>, etc.)underlying the therapeutic action of TFA in DKD. This evidence concerns the gene JUNB and diabetic kidney disease.