For instance, Bacteroides caccae, a biomarker of inflammatory bowel disease (IBD) [60], showed a positive correlation with PLCB1 in T, a gene frequently upregulated in cancer [61], but a negative correlation in A and P. Similarly, interactions between Methanobrevibacter_A smithii_A and FBXW9 (a proposed biomarker and therapeutic target in breast cancer) [62] shifted from weak or absent in A/P to significantly positive in T. This evidence concerns the gene PLCB1 and irritable bowel syndrome.