CD4 and cancer: This observation was further corroborated by TCGA data set analysis, which revealed a consistent inverse correlation between C9ORF50 expression and the infiltration of various lymphoid cell populations, including CD8+ T cells, Th1, Th2, CD4+ memory T cells, and plasma cells across multiple human cancer types (e.g., STAD, LUSC, CESC; Figure 7F,G).