Low levels of miR-532-5p are closely associated with higher lymphatic vessel density (D2-40–positive) and the tube formation ability of human lymphatic endothelial cells (HLECs), suggesting that it promotes lymphangiogenesis and metastasis by remodeling the tumor microenvironment (21).Mechanistic studies indicate that miR-532-5p directly targets the 3′UTR of fatty acid synthase (FASN), downregulating its expression and thereby inhibiting lipid synthesis and LD accumulation (21). The gene discussed is FASN; the disease is neoplasm.