In Ulcerative Colitis (UC) models, APS also restores the balance of Th17/Treg cells (decreasing Th17 cells and increasing Treg cells) by inhibiting the abnormal activation of the TIGIT/CD155 signaling pathway and reducing the protein levels of PI3K, AKT, and p-AKT (138–140). Here, AKT1 is linked to ulcerative colitis.