Furthermore, expression of IL-6 was reduced in islets of donors with T1D (167) and it has been shown that IL-6 couples autophagy to antioxidant response, reducing reactive oxygen species (ROS) in beta cells, leading to stress adaptation and reducing cellular apoptosis, thereby protecting human islets from inflammatory stress-induced apoptosis (168, 169). The gene discussed is IL6; the disease is type 1 diabetes mellitus.