For instance, the Z-type TiO2@CeO2 nanozyme/SDT/immunotherapy synergistic platform induces ICD through the SDT effect of TiO2, while CeO2 nanozymes alleviate tumor hypoxia and scavenge excess ROS via superoxide dismutase (SOD)-like and catalase (CAT)-like activities, achieving precise immune activation without damaging normal tissues (103). This evidence concerns the gene CAT and neoplasm.