Shu Hong and colleagues successfully delivered STAT6 siRNA using poly PLGA-polyethylenimine (PEI) nanobubbles in conjunction with ultrasound-mediated nanobubble disruption, enhancing the transfection of PLGA-PEI NBs-STAT6 siRNA in M2-like macrophages, reprogramming them into M1-like macrophages, and inhibiting the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of non-small cell lung cancer cells (128). Here, STAT6 is linked to non-small cell lung carcinoma.