IL1B and pemphigus foliaceus: The signal that triggers the upstream activation of inflammasomes is via TLRs while it binds to PAMPs or DAMPs, this induces inflammasome expression (160) (Figure 2B). BLM can trigger inflammasomes which lead to PF via IL-1β/IL-1Rs/MyD88/NF-κB signaling axis (160, 161).