- Both FMF and SLE involve inflammation, fever, arthritis, serositis (pericarditis, pleuritis, peritonitis), and renal/musculoskeletal involvement- Dysregulated inflammasomes and pro-inflammatory cytokines (TNF, IL-1, IL-6, IL-18)- High levels of CRP and SAP in FMF aids in apoptotic debris clearance. Here, IL1B is linked to familial Mediterranean fever.