CD8A and Alzheimer disease: In this regard, it is worth noting that, though we also found no difference in CD8 + T cell abundance in AD in ROSMAP samples derived from the hippocampus, this represents a much smaller dataset than the PFC, and we were unable to replicate the LPM finding from Sun et al. (2023) in the hippocampus (data not shown), suggesting we might be underpowered to detect changes in the hippocampal dataset.