The emerging picture from our current findings combined with others 19,25,26, necessitate consideration of eGlyR dysregulation in addition to conventional NMDARs as an underlying feature of neurological disorders associated with genetic mutations or alterations in GRIN3A expression such as schizophrenia, bipolar disorder, addiction, epilepsy, and Huntington’s Disease 13,32–39. This evidence concerns the gene GRIN3A and Huntington disease.