Leveraging patient datasets from The Cancer Genome Atlas (TCGA), Genotype‐Tissue Expression (GTEx), Clinical Proteomic Tumor Analysis Consortium (CPTAC) and complementary resources, we examine DCAF7 expression, prognostic value, genetic alterations, epigenetic regulation, single‐cell function, immune‐cell infiltration and drug‐sensitivity profiles across 33 cancers. Here, DCAF7 is linked to neoplasm.