BTN3A3 restricts avian IAV replication in primate airways; ICAM1 and CEACAM1 are induced in influenza-infected cells; CSF3R signaling exacerbates influenza-associated lung injury; LBP mediates lethal TLR4-dependent inflammation; HRG regulates vascular and coagulation pathways disrupted in severe flu. Here, BTN3A3 is linked to influenza.