TMPRSS2 and COVID-19: However, Kehdy et al., 2021 [11] reinforced the need to evaluate Linkage Disequilibrium (LD) with other alleles in the same gene, which might also intervene in the pathophysiology of COVID-19, citing rs383510, whose relationship with the SNPs is also evidenced by Cheng et al., 2015 [23], who defended the hypothesis that rs2070788, although located in an intronic region, does not represent a regulatory region and does not directly affect TMPRSS2 expression.