PPBP and viral load: For instance, self-interaction of the cucumber mosaic virus (CMV) 2b protein plays a vital role in the suppression of RNA silencing and the induction of viral disease symptoms [29]; self-interaction of the rice stripe virus (RSV) NP protein is essential for its localization in the nucleus [30]; self-interaction of the potato mop-top virus (PMTV) TGB1 protein is needed for cell-to-cell movement [31]; and the self-interaction of the RSV NS3 protein proves indispensable for countering host defenses by suppressing RNA silencing [32].