In a study developed by Moreira et al. [46] in a Brazilian population in the state of Paraná, a significant association was reported between the presence of the heterozygous genotype G/C of the SNP -174 G/C in the IL-6 gene as a protective factor against the development of dengue fever, with this genotype present more frequently in the control group compared to the case group. This evidence concerns the gene IL6 and dengue disease.