This mechanism was investigated in studies of LPS-induced bovine endometritis, and it was observed that α7nAChR agonists have a protective effect on the endometrium by promoting the reduction in COX2/mPGES-1 activity via inhibition of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway [67]. This evidence concerns the gene STAT3 and endometritis.