ASZ1 and infection: (4) Conclusions: In this study, differential genes involved in regulating host cell innate immunity, maintaining ERK activity, inhibiting growth factor transport, and inhibiting immune response processes were successfully screened in HepG2 cells expressing ORF3 in HEV-4 in swine, and the regulatory networks of circRNA-miRNA and lncRNA-mRNA were predicted, respectively, which laid a foundation for further elucidating the function of swine hepatitis E virus ORF3 and elucidating the infection mechanism of swine hepatitis E virus.