Research indicates that GNB1 can enhance cell proliferation, colony formation, cell migration, and invasion in vitro, and promotes the epithelial-to-mesenchymal transition process of HCC cells, thereby facilitating the progression of hepatocellular carcinoma through the activation of the P38/MAPK signaling pathway by targeting BAG2 [21]. The gene discussed is GNB1; the disease is hepatocellular carcinoma.