Six spacers (sp40, sp347, sp533, sp536, sp623, and sp874) matching sequences on the pO157 hybrid plasmid of IncFIA:FIB:FII group (GenBank NZ_ABHM02000004.1) carrying a set of virulence genes (hlyABCD, eptO, gspCDEFGHIJKL, stcE, ibeC, and espP) specific for two pathotypes, Enterohemorrhagic E. coli (EHEC) and Enteroinvasive- and Meningitis-associated E. coli (EIEC/MNEC). This evidence concerns the gene CLU and infectious meningitis.