SERPINH1 and acne: The enrichment of adhesion factors, such as EbpS (Elastin-binding protein, VF0008), FbpA (Fibronectin-binding protein, VF0349), CAN (Collagen-Binding Protein, VF0005), and SDr (Serine-Aspartate Repeat proteins, VF0019) in the acne group suggests an enhanced capacity for bacterial attachment to host extracellular matrix components, a critical first step in colonization and biofilm formation [21,22,23,24].