Analysis of differential metabolic pathways revealed significantly higher relative abundances of carbon metabolism, glycine-serine-threonine metabolism, glyoxylate and dicarboxylate metabolism, the citrate cycle (TCA cycle), arginine biosynthesis, nitrogen metabolism, fatty acid biosynthesis, biotin metabolism, teichoic acid biosynthesis, ABC transporters, protein export, and Caulobacter cell cycle in the acne group compared with the healthy group (p < 0.05). This evidence concerns the gene ABCG2 and acne.