In pSS patients, Faecalibacterium prausnitzii was negatively associated with GGT and ALT, while in the HC group, Pediococcus acidilactici was positively correlated with C3 and hemoglobin (Hb) and negatively correlated with IgG, and Roseburia inulinivorans was negatively associated with GGT and ALT. The gene discussed is GSTM1; the disease is peeling skin syndrome.