NOTCH3 signaling activation has been associated with various viral infection pathologies: HIV Tat protein drives neuroinflammation by enhancing NOTCH3 signaling [33]; SARS-CoV-2 infection in alveolar foci is accompanied by NOTCH3 upregulation [34]; and HCV NS3 protein promotes persistent infection by modulating the Notch pathway through SRCAP/p400 [15]. Here, EP400 is linked to viral infectious disease.