NOTCH3 signaling activation has been associated with various viral infection pathologies: HIV Tat protein drives neuroinflammation by enhancing NOTCH3 signaling [33]; SARS-CoV-2 infection in alveolar foci is accompanied by NOTCH3 upregulation [34]; and HCV NS3 protein promotes persistent infection by modulating the Notch pathway through SRCAP/p400 [15]. This evidence concerns the gene TAT and viral infectious disease.